* Indicates in-season trade
| Trade # | Team | Traded | To | For |
|---|---|---|---|---|
| 560 | Rambler | Matt Holliday | Oil Barons | Carl Crawford / Mike Minor |
| 559 | Moondogs | Jhonny Peralta / Scott Downs | Oil Barons | Dee Brown / 2012 1st RDP |
| 558 | Redhawks | Mitch Maier | Frogs | Brooks Conrad |
| 557 | Sandlappers | Miguel Olivo / Martin Prado Rafael Soriano / D.J. LeMahieu 2012 1st RDP |
Warriors | Michael Young / Alfredo Aceves Chris Snyder / Ryan Sweeney 2012 4th RDP |
| 556 | Jack Rabbits | Dave Sappelt / Luis Montanez | Moondogs | Mark Kotsay |
| 555 | Grays | 2012 3rd RDP | Farmers | J.C. Romero / 2012 5th RDP |
| 554 | Generals | Carlos Corporan | Moondogs | Jason Michaels |
| 553 | T-Bones | Frank Herrmann | Farmers | 2012 6th RDP |
| 552 | Dynamo | Randall Delgado / Charlie Blackmon 2012 1st RDP |
Generals | Roy Halladay |
| 551 | Redhawks | Juan Uribe / Bill Hall | Thunder | Travis Buck / Enerio Del Rosario |
| 550 | Rockets | Chad Qualls | Farmers | 2012 3rd RDP |
| 549 | T-Bones | 2012 4th RDP | Rambler | Alberto Gonzalez |
| 548 | Grays | Chris Young /2012 1st RDP | Oil Barons | Dexter Fowler / 2012 2nd RDP |
| 547 | Redhawks | 2012 8th RDP | Owls | Bill Hall |
| 546 | Jack Rabbits | 2012 5th RDP | Barking Seals | Doug Davis / Ramon Castro |
| 545 | Storm Giants | Josh Spence | Aesir | Jose Iglesias |
| 544 | Rambler | Kevin Slowey | Redhawks | 2012 3rd RDP |
| 543 | Redhawks | Zach Duke / Koyie Hill 2012 2nd RDP |
Jack Rabbits | Clayton Richard / DeWayne Wise |
| 542 | Owls | Colby Lewis / Blake Dewitt | Jack Rabbits | Brett Cecil / Brent Lillibridge 2012 3rd RDP |
| 541 | Dynamo | 2011 1st RDP(#24) / 2011 5th RDP(#15) | Barking Seals | 2011 1st RDP(#21) |
| 540 | Barking Seals | 2011 1st RDP(#6) / 5th RDP (#3) | Storm Giants | 2011 1st RDP (#18) / 2011 1st RDP (#21) |
| 539 | Owls | George Kotteras / 2011 5th RDP(#19) | Moondogs | Robert Andino |
| 538 | Rockets | 2011 2nd RDP(#13) | Moondogs | Mark Melancon |
| 537 | Oil Barons | Wade Davis / Matt Gamel | Zeppelins | 2011 2nd RDP(#1) / 4th RDP(#25) |
| 536 | Terriers | Clay Buchholz / Jon Jay | Rockets | Guillermo Moscoso / Grady Sizemore 2011 1st RDP(#14) |
| 535 | Grays | Angel Pagan | Jack Rabbits | 2011 3rd RDP(#24) |
| 534 | Grays | Aubrey Huff / Kevin Correia Matt Reynolds |
Barking Seals | Carlos Pena / 2011 2nd RDP(#3) |
| 533 | Grays | Logan Ondrusek / Andrew Bailey | Tigers | 2011 2nd RDP(#4) |
| 532 | Frogs | Juan Pierre | Tigers | 2011 3rd RDP(#1) |
| 531 | Jack Rabbits | Brett Wallace / Marlon Byrd | Reptiles | Ryan Raburn / Ty Wigginton |
| 530 | Frogs | John Jaso / Hasinori Takahashi | Redhawks | Jayson Nix / Eric Chavez Francisco Cordero |
| 529 | Frogs | Shin Soo Choo | Owls | Neil Walker / Andruw Jones |
| 528 | Terriers | Nick Evans / Drew Sutton Brooks Conrad |
Frogs | Mike Pelfrey |
| 527 | Storm Giants | Phillip Humber / Dustin Moseley | Aesir | Alexi Casilla / 2011 1st RDP(#18) |
| 526 | Dynamo | 2011 3rd RDP(#22) | Jack Rabbits | Hideki Matsui / 2011 5th RDP(#24) |
| 525 | Grays | Coco Crisp | Farmers | 2011 3rd RDP(#14) |
| 524 | Owls | John Buck / Luke Hughes Mike Pelfrey / 2011 3rd RDP(#27) |
Frogs | 2011 2nd RDP(#16) / 2011 5th RDP(#16) |
| 523 | Redhawks | Chris Getz / 2011 5th RDP(#15) | Dynamo | Bobby Abreu |
| 522 | Terriers | Chris Young | Grays | Mark Trumbo |
| 521 | Rockets | Gaby Sanchez / 2011 4th RDP(#5) | Storm Giants | David Ortiz |
| 520 | Redhawks | Alex Gonzalez | Zorros | Joe Saunders |
| 519 | Redhawks | Brent Lillibridge | Jack Rabbits | Paul Yanish |
| 518 | Redhawks | Ryan Howard / Phillip Humber Chris Perez / 2011 2nd RDP(#26) |
Storm Giants | Starlin Castro / Roy Oswalt Heath Bell |
| 517 | Redhawks | Yadier Molina | Rockets | Jarrod Saltalamacchia / Marco Estrada 2011 2nd RDP(#26) |
| 516 | Storm Giants | Dayan Viciedo | Reptiles | Denard Span |
| 515 | Redhawks | Torii Hunter / Micah Owings | Aesir | Adam Lind |
| 514 | Reptiles | Jered Weaver / 2011 5th RDP(#18) | Farmers | Hank Conger / Trevor Cahill |
| 513 | Grays | Chris Ianetta / Seth Smith | Blue Crabs | 2011 1st RDP(#4) |
| 512 | Dynamo | Justin Morneau | Zeppelins | 2011 2nd RDP(#2) |
| 511 | Reptiles | Dustin Pedroia | Zeppelins | Stephen Strasburg |
| 510 | Jukes | Joey Votto / Max Scherzer | Oil Barons | Matt Weiters / Freddie Freeman |
| 509 | Jack Rabbits | Julio Borbon / Willie Bloomquist | Zorros | Don Kelly / Laynce Nix |
| 508 | Reptiles | Danny Valencia / 2011 4th RDP(#27) | Jack Rabbits | Casey McGehee / Ronny Cedeno Jose Veras |
| 507 | Sandlappers | Neil Walker | Owls | Gavin Floyd |
| 506 | Jack Rabbits | Martin Prado | Sandlappers | Omar Infante |
| 505 | Rockets | 2011 3rd RDP(#9) | Reptiles | Kyle Farnsworth |
| 504 | Dynamo | Alex Rodriguez / Phil Hughes | Damage | Shane Victorino |
| 503 | Grays | Brett Wallace | Jack Rabbits | Chris Volstad |
| 502 | Redhawks | Jarrod Saltalamacchia | Rockets | Darwin Barney |
| 501 | Rebels | Kevin Corriea | Grays | Jonathan Herrera / 2011 4th RDP |
| 500 | Grays | David Frese | Redhawks | Javier Vasquez / Owls 2011 2nd RDP |
| 499* | Grays | Scott Hairston | Jack Rabbits | 2011 5th RDP |
| 498* | Rockets | Raul Ibanez | Aesir | 2011 3rd RDP |
| 497* | Storm Giants | 2011 6th RDP | Zorros | Pedro Feliz |
| 496* | Redhawks | Tim Hudson | Owls | Phillip Humber / 2011 2nd RDP |
| 495* | Aesir | Freddie Freeman | Oil Barons | Ervin Santana |
| 494* | T-Bones | David Freese / Aubrey Huff | Grays | Derek Lee / Andy LaRoche 2011 1st RDP |
| 493* | Rockets | Rafael Soriano / Nick Swisher Russell Branyan |
Sandlappers | Lance Berkman / Corey Hart 2011 2nd RDP |
| 492* | Rockets | Roy Oswalt / 2011 3rd RDP | Storm Giants | Jordan Zimmerman / 2011 4th RDP |
| 491* | Farmers | Nolan Reimold | Buskers | Chris Resop |
| 490* | Grays | Nate Robertson / 2011 3rd RDP | Zeppelins | Carlos Silva |
| 489 | Redhawks | Joaquin Arias | Zorros | Fernando Tatis |
| 488 | Redhawks | Brad Ausmus | Jack Rabbits | Brandon Moss |
| 487 | Jack Rabbits | Brian Schneider | Dynamo | Willie Bloomquist |
| 486 | Damage | Ryan Hanigan | Dynamo | 2011 2nd RDP |
| 485 | Jack Rabbits | Brian Roberts / John Jay Russell Martin |
Terriers | Alcides Escobar / Julio Borbon Brian Schneider |
| 484 | Jack Rabbits | Darwin Barney | Rockets | Jody Gerut |
| 483 | Redhawks | Aaron Harang | Tigers | Koyie Hill |
| 482 | Moondogs | Jenrry Mejia / Alberto Callaspo | Farmers | Jhonny Peralta / 2011 2nd RDP |
| 481 | Moondogs | Adam Kennedy / 2011 1st RDP 2011 3rd RDP |
Zeppelins | Kelly Johnson / Juan Rivera 2011 5th RDP |
| 480 | Redhawks | Matt Albers | Tigers | Micah Owings |
| 479 | Zeppelins | Carlos Lee | Dynamo | 2011 4th RDP |
| 478 | Redhawks | 2011 1st RDP | Farmers | Eric Young Jr. |
| 477 | Redhawks | Carlos Fisher | Titans | Eric Chavez |
| 476 | Rambler | Craig Breslow | Buskers | 2011 1st RDP |
| 475 | Frogs | Eddie Bonine | Jack Rabbits | Jonathan Albaledejo / Brandon Boggs |
| 474 | Rebels | Hideki Matsui | Jack Rabbits | Chris Denorfia / Joe Smith |
| 473 | Jack Rabbits | Augie Ojeda / Jarrett Hofpauir Anderson Hernandez / Willy Taveras |
Rebels | 2011 5th RDP |
| 472 | Owls | Joe Smith / Chris Snyder Paul Maholm / 2011 4th RDP |
Jack Rabbits | George Kottaras / 2011 2nd RDP |
| 471 | Redhawks | 2011 2nd RDP | Damage | Brandon League / Vicente Padilla |
| 470 | Jack Rabbits | 2011 4th RDP | Farmers | Dewayne Wise / Tony Pena |
| 469 | Redhawks | Luke Scott / 2011 4th RDP | T-Bones | Josh Willingham / Manny Acosta Esmailin Caridad |
| 468 | Redhawks | Vladimir Guerrero | Rebels | Francisco Cordero / Mitch Maier |
| 467 | Zeppelins | Ryan Theriot | Blue Crabs | 2011 2nd RDP / 2011 3rd RDP |
| 466 | Jukes | Chris Tillman | Rambler | Eric O'Flaherty |
| 465 | Terriers | Pedro Feliz / Josh Wilson | Titans | Delwyn Young / Brian Schneider |
| 464 | Oil Barons | Bobby Crosby | Rockets | 2011 4th RDP |
| 463 | Owls | Mark Rogers | Aesir | Andy Pettitte / Jason Giambi |
| 462 | Damage | Jose Valverde / Darnell McDonald | Sandlappers | 2011 1st RDP |
| 461 | Dynamo | 2010 7th RDP(#18) | Sandlappers | 2010 7th RDP(#25) / 2010 8th RDP(#25) |
| 460 | Rebels | 2010 1st RDP (#23) | Oil Barons | 2010 2nd RDP(#7) / 2010 2nd RDP (#8) |
| 459 | Owls | Jim Thome | Dynamo | 2010 2nd RDP(#22) |
| 458 | Moondogs | Antonio Bastardo / Ross Detwiler | Rebels | 2010 5th RDP(#23) |
| 457 | Moondogs | Brett Hayes / Jason Repko | Frogs | 2010 5th RDP(#20) |
| 456 | Jack Rabbits | Andruw Jones | Owls | 2010 4th RDP(#8) |
| 455 | Rhinos | Scott Baker / Edison Volquez | Rockets | 2010 5th RDP(#16) / 2010 6th RDP(#16) |
| 454 | Redhawks | Travis Hafner | Buskers | 2010 4th RDP(#24) |
| 453 | Moondogs | Tony Abreu | Terriers | 2010 4th RDP(#22) |
| 452 | Frogs | 2010 4th RDP(#20) | Jack Rabbits | Craig Counsell / Wilson Valdez Chris Giminez |
| 451 | Zeppelins | Chris Denorfia / Jason Berken | Jack Rabbits | Ramiro Pena / 2010 5th RDP(#2) |
| 450 | Terriers | Ted Lilly | Redhawks | 2010 3rd RDP (#28) |
| 449 | Redhawks | Nelson Figueroa | Rhinos | Jarrod Saltalamacchia |
| 448 | Jack Rabbits | Skip Schumaker | T-Bones | Brian Roberts / Ben Francisco |
| 447 | Redhawks | Ed Mujica | T-Bones | Jason Bay / Travis Hafner |
| 446 | Redhawks | David Eckstein | Frogs | 2010 3rd RDP(#28) |
| 445 | Grays | Adam Rosales | Dynamo | 2010 3rd RDP(#21) |
| 444 | Frogs | Mitch Talbot | Buskers | 2010 2nd RDP(#27) / 2010 5th RDP(#24) |
| 443 | Sandlappers | Carlos Lee / Juan Gutierrez Armando Galarraga / Ryan Rowland-Smith |
Zeppelins | Jon Garland |
| 442 | Sandlappers | Casey McGehee / Skip Schumaker Alex Avila |
Jack Rabbits | Scott Rolen / Fred Lewis Joaquin Benoit |
| 441 | Redhawks | Aaron Cook / Justin Duchscherer 2010 6th RDP(#9) |
Owls | Bobby Jenks / Aaron Heilmann Matt Albers |
| 440 | Jack Rabbits | Cesar Izturis | Rhinos | Andruw Jones |
| 439 | Redhawks | Ramiro Pena | Jack Rabbits | 2010 6th RDP(#2) |
| 438 | Zeppelins | Jose Lopez / Garrett Jones | Blue Crabs | Jose Reyes / 2010 1st RDP(#7) 2010 2nd RDP(#9) |
| 437 | Zeppelins | David Wright / Gordon Beckham | Oil Barons | Chase Headley / Kelly Johnson 2010 1st RDP(#6) |
| 436 | Jack Rabbits | Dice-K Matsuzaka | Rockets | Joaquin Benoit |
| 435 | Jack Rabbits | Gerardo Parra / Jeff Keppinger Wil Nieves |
Jukes | Fred Lewis / Ronny Cedeno |
| 434 | Jack Rabbits | David Freese / Brian Mohler | T-Bones | Craig Counsell / Jeff Keppinger |
| 433 | Dynamo | Troy Glaus / 2010 4th RDP (#9) | Jack Rabbits | 2010 3rd RDP (#21) / 2010 4th RDP (#2) |
| 432 | Owls | Phil Coke | Farmers | 2010 3rd RDP (#17) |
| 431 | Sandlappers | Jayson Nix | Redhawks | 2010 5th RDP (#9) |
| 430 | Aesir | 2010 3rd RDP(#18) | Moondogs | Trevor Crowe |
| 429 | Redhawks | Nyjer Morgan / Kevin Kouzmanoff | Barking Seals | Colby Rasmus |
| 428 | Grays | Brandon Morrow / 2010 1st RDP(#13) | Damage | Dan Uggla / 2010 2nd RDP (#19) |
| 427 | Frogs | Aaron Cook / Nyjer Morgan | Redhawks | Jacoby Ellsbury |
| 426 | Jukes | Alex Gonzalez | Red Hawks | 2010 2nd RDP (#13) |
| 425 | Grays | A.J.Pierzynski / James MacDonald Chris Capuano / Boone Logan |
Tigers | 2010 1st RDP(#13) |
| 424 | Jukes | Ryan Ludwick / Josh Willingham Mike Aviles / Grant Balfour Brian Sanches |
T-Bones | 2010 1st RDP (#19) / 2010 2nd RDP(#23) 2010 3rd RDP(#19) |
| 423 | Owls | Matt Kemp / Brandon Allen Brandon League |
Damage | Jose Bautista |
| 422 | Oil Barons | Joba Chamberlain / Garrett Jones | Zeppelins | 2010 2nd RDP (#7) |
| 421 | Aesir | Corey Hart | Sandlappers | Brandon Phillips / Aramis Ramirez |
| 420 | Oil Barons | Jesse Crain | Dynamo | 2010 4th RDP (#18) |
| 419 | Rebels | Ivan Rodriguez | Blue Crabs | David Hernandez |
| 418 | Owls | Fernando Martinez /Clayton Mortensen Juan Francisco |
Zeppelins | Brian Wilson / Bill Hall |
| 417 | Frogs | Brian McCann | Grays | Daniel Hudson / Mitch Talbot John Jaso |
| 416 | Dynamo | Jerry Hairston Jr. | Redhawks | Troy Glaus |
| 415 | Dynamo | Aaron Harang | Redhawks | 2010 4th RDP |
| 414 | T-Bones | Javier Vazquez | Redhawks | Kevin Millwood |
| 413 | Oil Barons | Tom Gorzelanny | Redhawks | 2010 3rd RDP |
| 412 | Rockets | Phil Coke / John Buck Jim Thome |
Owls | Gaby Sanchez / Howie Kendrick |
| 411 | Owls | Tim Hudson / Jake Westbrook | Redhawks | 2010 1st RDP |
| 410 | Oil Barons | Scott Kazmir | Zeppelins | 2010 3rd RDP |
| 409* | Farmers | Ryan Rowland-Smith | Sandlappers | 2010 3rd RDP |
| 408* | Damage | Dewayne Wise | Farmers | 2010 6th RDP |
| 407* | Owls | Albert Callaspo / Michael Barrett | Moondogs | Brandon League / Chris Coste |
| 406 | Peppers | 2010 7th RDP | Fiddlers | Josh Greer |
| 405 | Hillbillies | Esteban German | Fiddlers | Matt Kata |
| 404 | Fiddlers | 2010 6th RDP | Moondogs | Chris Duncan |
| 403 | Dynamo | Jason Giambi | Fiddlers | Joel Hanrahan |
| 402 | Rockets | Derek Lowe / 2010 1st RDP 2010 3rd RDP |
Farmers | Carlos Zambrano |
| 401 | Farmers | Ramon Castro | Dynamo | Wesley Wright |
| 400 | Rockets | Scott Downs / 2010 2nd RDP | Moondogs | Phil Coke / Russell Branyan |
| 399 | Rockets | 2010 4th RDP | Rambler | Eric Bruntlett |
| 398 | Dynamo | Randy Winn / Chris Dickerson Doug Fister |
Frogs | Magglio Ordonez / Matt Joyce Cla Meredith | 397 | Oil Barons | Juan Rivera | Zeppelins | 2010 1st RDP |
| 396 | Grays | 2010 1st RDP | Oil Barons | Carlos Beltran / 2010 3rd RDP |