| Name | Name | ERA |
| Curt Simmons* | Larks | 2.25 |
| Bob Lemon | Carp | 2.50 |
| Ned Garver | Larks | 2.58 |
| Johnny Schmitz* | Muck Dogs | 2.59 |
| Hoyt Wilhelm | Aces | 2.65 |
| Paul Minner* | Clowns | 2.92 |
| Virgil Trucks | Muck Dogs | 3.01 |
| Mike Garcia | Grays | 3.15 |
| Robin Roberts | Muck Dogs | 3.19 |
| Jim Davis* | Aces | 3.21 |
| Vic Raschi | Arsenal | 3.28 |
| Sandy Consuegra | Blues | 3.32 |
| Gordon Jones | Aces | 3.32 |
| Joe Nuxhall* | Grays | 3.34 |
| Tom Poholsky | Aces | 3.42 |
| Gene Conley | Larks | 3.49 |
| Hal Brown | Muck Dogs | 3.53 |
| Early Wynn | Walleye | 3.53 |
| Don Johnson | Aces | 3.56 |
| Jim Hearn | Grays | 3.57 |
| Chuck Stobbs* | Larks | 3.57 |
| Ruben Gomez | Hawks | 3.65 |
| Bob Rush | Carp | 3.67 |
| Herm Wehmeier | Muck Dogs | 3.70 |
| Dean Stone* | Aces | 3.76 |
| Dave Jolly | Thunderbolts | 3.83 |
| Don Liddle* | Blues | 3.86 |
| Tom Brewer | Carp | 3.93 |
| Bob Friend | Clowns | 3.93 |
| Lew Burdette | Walleye | 3.95 |
| Whitey Ford* | | 3.99 |
| Harvey Haddix* | Tigers | 4.02 |
| Bob Porterfield | Clowns | 4.02 |
| Harry Dorish | Arsenal | 4.03 |
| Duane Pillette | Aces | 4.04 |
| Billy Pierce* | | 4.08 |
| Johnny Antonelli* | Tigers | 4.08 |
| Steve Gromek | Grays | 4.11 |
| Allie Reynolds | Hawks | 4.11 |
| Bob Feller | Walleye | 4.16 |
| Chet Nichols* | Hawks | 4.17 |
| Arnie Portocarrero | Grays | 4.18 |
| Eddie Lopat* | Thunderbolts | 4.29 |
| Bob Grim | Clowns | 4.30 |
| Warren Spahn* | Stampers | 4.33 |
| Bob Keegan | Clowns | 4.34 |
| Art Houtteman | Arsenal | 4.40 |
| Art Fowler | Blues | 4.43 |
| Steve Ridzik | Stampers | 4.45 |
| Johnny Podres* | Walleye | 4.49 |
| Jack Harshman* | Muck Dogs | 4.52 |
| Royce Lint* | Thunderbolts | 4.56 |
| Bob Turley | Royal Giants | 4.56 |
| Vern Law | | 4.59 |
| George O'Donnell | Thunderbolts | 4.63 |
| Dave Cole | Walleye | 4.64 |
| Willard Nixon | Blues | 4.65 |
| Frank Sullivan | Tigers | 4.66 |
| Corky Valentine | Carp | 4.71 |
| Harry Byrd | Carp | 4.77 |
| Jim Wilson | Tigers | 4.83 |
| Russ Meyer | Royal Giants | 4.84 |
| Morrie Martin* | Royal Giants | 4.88 |
| Dick Littlefield* | Walleye | 4.89 |
| Russ Kemmerer | Royal Giants | 4.99 |
| Billy Loes | Hawks | 5.02 |
| Warren Hacker | Stampers | 5.04 |
| Leo Kiely* | Stampers | 5.08 |
| Max Surkont | Thunderbolts | 5.10 |
| Marion Fricano | Blues | 5.13 |
| Al Aber* | Stampers | 5.17 |
| Brooks Lawrence | Thunderbolts | 5.34 |
| Billy Hoeft* | Arsenal | 5.35 |
| Murry Dickson | Aces | 5.35 |
| Jake Thies | Hawks | 5.36 |
| Bob Buhl | Larks | 5.36 |
| Mickey McDermott* | | 5.39 |
| Don Larsen | Arsenal | 5.47 |
| Bob Purkey | Hawks | 5.52 |
| George Zuverink | Grays | 5.57 |
| Joe Coleman | Tigers | 5.59 |
| Sal Maglie | Clowns | 5.68 |
| Paul LaPalme* | Stampers | 5.77 |
| Johnny Klippstein | Walleye | 5.80 |
| Fred Baczewski* | Blues | 5.92 |
| Gerry Staley | Blues | 6.09 |
| Lou Kretlow | Royal Giants | 6.37 |
| Harry Perkowski* | Royal Giants | 6.42 |
| Alex Kellner* | Stampers | 6.48 |
| Bill Henry* | Hawks | 6.50 |
| Carl Erskine | Thunderbolts | 6.79 |
| Bob Trice | Royal Giants | 7.04 |
| Howie Pollet* | Tigers | 7.71 |
| Cot Deal | Stampers | 7.73 |
| Ray Herbert | Royal Giants | 7.76 |