| Name | Name | ERA |
| John Candelaria* | Peppers | 1.59 |
| Mark Eichhorn | Rats | 1.87 |
| Roger Clemens | Mets | 2.45 |
| Ricky Horton* | Spiders | 2.46 |
| Bruce Hurst* | Hoosiers | 2.67 |
| Bob Sebra | Spiders | 2.82 |
| Dwight Gooden | Tigers | 2.85 |
| Dan Plesac* | Thunder | 2.93 |
| Bob Knepper* | Mountaineers | 2.95 |
| Ron Guidry* | Hoosiers | 2.96 |
| Dave Dravecky* | Hoosiers | 3.01 |
| Scott Sanderson | Mountaineers | 3.02 |
| Orel Hershiser | Thunder | 3.13 |
| Jose Guzman | Tigers | 3.17 |
| Tom Candiotti | Scotties | 3.18 |
| Mike Scott | Flames | 3.21 |
| Jose DeLeon | Tigers | 3.24 |
| Teddy Higuera* | Tourists | 3.24 |
| Mark Portugal | Rats | 3.24 |
| Don Sutton | Mountaineers | 3.24 |
| Kent Tekulve | Rats | 3.30 |
| Fernando Valenzuela* | Flames | 3.33 |
| Mike Moore | Eagles | 3.34 |
| Bobby Ojeda* | Scotties | 3.34 |
| Mike Mason* | Peppers | 3.35 |
| Floyd Bannister* | Volcanoes | 3.38 |
| Shane Rawley* | Eagles | 3.42 |
| John Tudor* | Spiders | 3.42 |
| Bob Welch | Mets | 3.45 |
| Kelly Downs | Brushbacks | 3.50 |
| Bob Forsch | Forest Citys | 3.51 |
| Sid Fernandez* | Mets | 3.55 |
| Danny Darwin | Lynx | 3.57 |
| Jimmy Key* | Lynx | 3.59 |
| Mark Gubicza | Eagles | 3.59 |
| Eric Show | Scotties | 3.59 |
| Charlie Hough | Mountaineers | 3.61 |
| Jim Clancy | Pelicans | 3.61 |
| Charlie Leibrandt* | Hoosiers | 3.62 |
| Zane Smith* | Mountaineers | 3.63 |
| Danny Cox | Forest Citys | 3.68 |
| Mike Witt | Eagles | 3.69 |
| Tom Seaver | Rats | 3.71 |
| Bob Kipper* | Brushbacks | 3.71 |
| Curt Young* | Thunder | 3.75 |
| Neal Heaton* | Lynx | 3.77 |
| Gene Nelson | Mets | 3.79 |
| Jim Deshaies* | Thunder | 3.79 |
| Oil Can Boyd | Mets | 3.82 |
| Ken Dixon | Mountaineers | 3.83 |
| Danny Jackson* | Road | 3.86 |
| Andy McGaffigan | Highlanders | 3.89 |
| La Marr Hoyt | | 3.93 |
| Tom Browning* | Road | 4.01 |
| Storm Davis | Tigers | 4.01 |
| David Palmer | Lynx | 4.03 |
| Scott Bankhead | Peppers | 4.04 |
| Joaquin Andujar | Highlanders | 4.05 |
| Bert Blyleven | Mountaineers | 4.07 |
| Neil Allen | Scotties | 4.09 |
| Don Schulze | Volcanoes | 4.11 |
| Bill Gullickson | Alley Cats | 4.12 |
| Bud Black* | Brushbacks | 4.12 |
| Kevin Gross | Thunder | 4.12 |
| Ed Whitson | Highlanders | 4.22 |
| Nolan Ryan | Scotties | 4.23 |
| Mike Boddicker | Hoosiers | 4.28 |
| Scott Bailes* | Triangles | 4.28 |
| Bill Wegman | Peppers | 4.30 |
| Ron Darling | Eagles | 4.32 |
| Rick Rhoden | Flames | 4.35 |
| Dennis Leonard | Spiders | 4.36 |
| Jay Tibbs | Highlanders | 4.37 |
| Dennis Rasmussen* | Mets | 4.37 |
| Bryn Smith | Volcanoes | 4.39 |
| Mike Krukow | Road | 4.41 |
| Rich Bordi | Forest Citys | 4.42 |
| Phil Niekro | Eagles | 4.42 |
| Keith Atherton | Black Sox | 4.48 |
| Juan Nieves* | Road | 4.49 |
| Scott McGregor* | Highlanders | 4.55 |
| Dave Stewart | Pelicans | 4.55 |
| Rick Honeycutt* | Black Sox | 4.59 |
| Edwin Correa | Forest Citys | 4.61 |
| Mike Morgan | Thunder | 4.62 |
| Chris Codiroli | Lynx | 4.64 |
| Dennis Eckersley | Tigers | 4.66 |
| Scott Garrelts | Hoosiers | 4.68 |
| Bob Tewksbury | Rats | 4.68 |
| Bruce Ruffin* | Tourists | 4.70 |
| Joe Niekro | Eagles | 4.73 |
| Mike Flanagan* | Road | 4.74 |
| Doyle Alexander | Alley Cats | 4.83 |
| Rick Sutcliffe | Forest Citys | 4.83 |
| Eric Plunk | Triangles | 4.83 |
| Jack Morris | Pelicans | 4.87 |
| Dave Stieb | Tourists | 4.87 |
| Floyd Youmans | Highlanders | 4.91 |
| Doug Drabek | Volcanoes | 4.92 |
| Mike LaCoss | Brushbacks | 4.93 |
| Greg Mathews* | Thunder | 4.94 |
| Frank Tanana* | Black Sox | 4.97 |
| Eric King | Tigers | 4.98 |
| Mark Langston* | Rats | 5.02 |
| Dave LaPoint* | Volcanoes | 5.04 |
| Bobby Witt | Spiders | 5.06 |
| Al Nipper | Triangles | 5.06 |
| Bret Saberhagen | Hoosiers | 5.07 |
| Rick Reuschel | Alley Cats | 5.13 |
| Joe Cowley | Black Sox | 5.17 |
| Mike Smithson | Rats | 5.18 |
| Joel Davis | Pelicans | 5.18 |
| Andy Hawkins | Alley Cats | 5.19 |
| Joe Johnson | Black Sox | 5.24 |
| Chris Welsh* | Pelicans | 5.31 |
| Tim Leary | Hoosiers | 5.35 |
| Rick Aguilera | Peppers | 5.37 |
| John Denny | Black Sox | 5.38 |
| Frank Viola* | Rats | 5.40 |
| Ken Schrom | Tourists | 5.41 |
| Jim Acker | Volcanoes | 5.43 |
| Richard Dotson | Peppers | 5.47 |
| Vida Blue* | Triangles | 5.65 |
| Steve Trout* | Brushbacks | 5.65 |
| Mike Bielecki | Road | 5.68 |
| Tim Conroy* | Spiders | 5.83 |
| Walt Terrell | Alley Cats | 5.93 |
| Bill Swift | Flames | 6.09 |
| Dan Petry | Volcanoes | 6.11 |
| Ed Lynch | Peppers | 6.11 |
| Jamie Moyer* | Pelicans | 6.16 |
| Jose Rijo | Forest Citys | 6.24 |
| Kirk McCaskill | Black Sox | 6.52 |
| Rick Mahler | Triangles | 6.53 |
| Charles Hudson | Brushbacks | 6.53 |
| Jim Slaton | Forest Citys | 6.70 |
| Larry McWilliams* | Brushbacks | 6.99 |
| Mario Soto | Flames | 7.45 |
| Steve Carlton* | Triangles | 7.47 |